After the double, Brewers fans gave Weeks a standing ovation. He was then picked off attempting to steal third.
Before the game, the milestone was the furthest thing from Weeks' mind.
"Honestly, that's the first I've even known about it," Weeks said when asked about what it would mean to reach 500 hits. "I'm not real big on milestones like that."
Still, Weeks, who is in his seventh season of his big league career, said he would be happy to get hit No. 500.
"It's just one of those things that when it comes I'll, of course, appreciate it," Weeks said, "but for the most part it's just one of those things that, when it comes, it comes."
Weeks scored the Brewers' first run in the eighth after recording his 501st hit, also a double. Hit No. 502 was a single to drive in a run in the ninth.